GenomeNarrator: Private Clinical-Grade Genomic Analysis
GenomeNarrator is a genomic analysis platform that processes your 23andMe, AncestryDNA, or VCF genome file entirely in your browser. Your raw genetic data never leaves your device. No server upload, no third-party access. For $9.99 per analysis, you get comprehensive disease risk assessment, pharmacogenomics, ACMG secondary findings, and trait analysis across 1,000+ conditions.
How Genomic Analysis Works
Upload your genome file and the analysis runs 100% client-side, cross-referencing over 100,000 genetic variants against peer-reviewed databases including ClinVar, SNPedia, and the GWAS Catalog. No AI or large language model generates your results. Every finding is a deterministic match against published clinical data. Results include polygenic risk scores, pharmacogenomic drug interactions, ACMG v3.2 secondary findings across 81 genes, and ancestry breakdown. Learn more about our science and methodology.
Clinical Databases Behind Every Finding
Every variant in your report links to a peer-reviewed source:
- ClinVar: NIH's archive of clinical variant classifications from accredited labs worldwide. We require a 2-star minimum review status. Visit ClinVar at NCBI.
- SNPedia: Community-curated database of 60,000+ SNP entries with clinical significance and direct PubMed references. Visit SNPedia.
- GWAS Catalog: NHGRI-EBI catalog of published genome-wide association studies linking variants to traits and diseases. Visit the GWAS Catalog.
- CPIC: Clinical Pharmacogenomics Implementation Consortium guidelines for drug-gene interactions. Level A and B coverage for 26 genes. Visit CPIC.
- gnomAD v4.1: Population allele frequencies from the Genome Aggregation Database, used to contextualise variant rarity. Visit gnomAD.
Pharmacogenomics: How Your Genes Affect Medications
The pharmacogenomics section identifies how your CYP2C19, CYP2D6, VKORC1, DPYD, and SLCO1B1 variants affect your response to common medications including warfarin, clopidogrel, SSRIs, statins, and chemotherapy agents. All findings follow CPIC Level A and B guidelines. Read our pharmacogenomics guide to understand how star alleles and phenotype predictions work.
Disease Risk Across 1,000+ Conditions
Your report covers cardiovascular disease, cancer predisposition (including BRCA1/2 and Lynch syndrome via ACMG secondary findings), neurological conditions such as Alzheimer's disease (APOE), metabolic disorders, autoimmune conditions, and rare Mendelian diseases. Polygenic risk scores are computed from validated GWAS associations. Learn how genome-wide association studies translate into risk estimates.
Privacy by Architecture
GenomeNarrator was built from day one so that your genome file never touches a server. The entire analysis pipeline runs in your browser. There is no cloud processing step, no storage of your raw DNA, and no third-party analytics that touches your genetic data. This is not a policy commitment that can change — it is a technical constraint of the architecture. See our privacy policy for the full details.
Pricing
GenomeNarrator offers a free demo so you can see the full pipeline before purchasing. Full access to all 1,000+ conditions, pharmacogenomics, ACMG secondary findings, ancestry analysis, and PDF export is available for $9.99 per analysis, no subscription required. Your analysis history and results never expire.
Frequently Asked Questions
What genome file formats does GenomeNarrator support?
We support raw data files from 23andMe (.txt), AncestryDNA (.txt), MyHeritage, FTDNA, and standard VCF files in GRCh37 or GRCh38 format. Files up to 2 GB are supported. You do not need a premium subscription with your provider — just download the raw data file.
Is my genetic data private and secure?
Yes. Your genome file is analyzed entirely in your browser and never leaves your device. No upload, no server processing, no third-party access to your raw DNA. We never sell or share your genetic data.
How accurate is the genomic analysis?
Clinical variants are cross-referenced against ClinVar with a 2-star minimum review status and CPIC Level A pharmacogenomic guidelines. Polygenic risk scores use validated GWAS associations from the NHGRI-EBI Catalog. SNP arrays detect common variants; rare pathogenic variants and structural changes require clinical-grade whole genome sequencing for confirmation.
Do I need a 23andMe or AncestryDNA account to use GenomeNarrator?
No. You only need the raw data file, which you can download directly from your testing provider's website under account settings or data downloads. The analysis works with any raw genome file in the standard tab-separated SNP format.
How much does a genomic analysis cost?
You can preview your top findings for free. Full access to all conditions, pharmacogenomics, ancestry analysis, and PDF export is $9.99 per analysis — a one-time payment with no subscription. Visit our pricing page for full details.
What is the difference between a SNP array and whole genome sequencing?
SNP arrays (used by 23andMe and AncestryDNA) test around 600,000 to 700,000 pre-selected genetic positions. Whole genome sequencing reads every base pair in your genome. For most common disease risk and pharmacogenomics, SNP array data is sufficient. For rare disease diagnosis, BRCA confirmation, or comprehensive structural variant analysis, clinical whole genome sequencing is recommended. Read our guide on how genomes work for more.
Does GenomeNarrator use artificial intelligence to generate results?
No. Every finding is a deterministic lookup against ClinVar, SNPedia, CPIC, and the GWAS Catalog. No large language model or AI generates text in your report. The pipeline is open to review on our science page.
Ready to understand your genome? Start your analysis. Upload takes under a minute and reports are $9.99 with no subscription.