How GenomeNarrator Analyzes Your Genome

GenomeNarrator processes your genome using a deterministic bioinformatics pipeline with no AI-generated content. Every variant is matched against ClinVar, SNPedia, the GWAS Catalog, and CPIC guidelines.

Variant Identification

Your genome file is parsed client-side to extract rsids, genotypes, chromosome positions, and build version (GRCh37 or GRCh38). Coordinate lifting is performed where needed using a curated map of 53,000+ positions.

Clinical Classification

Variants are classified using ClinVar pathogenicity ratings (minimum 2-star review status), SNPedia magnitude scores, and CPIC pharmacogenomic phenotypes. See our pricing and analysis page.

Polygenic Risk Scoring

Polygenic risk scores use effect sizes and allele frequencies from published GWAS studies and population data from gnomAD v4.1. Bayesian posterior risk integrates prior population prevalence with individual variant burden. Learn more in our GWAS guide and pharmacogenomics guide.